Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.8.2 extracted from

  • Hill, C.M.; Wu, F.; Cheng, T.C.; DeFrank, J.J.; Raushel, F.M.
    Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters (2000), Bioorg. Med. Chem. Lett., 10, 1285-1288.
    View publication on PubMed
Search for more literature for 3.1.8.2

Application

Application Comment Organism
degradation enzyme catalyse the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents Alteromonas sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information comparison of kinetic constants of paraoxon analogs Alteromonas sp.

Organism

Organism UniProt Comment Textmining
Alteromonas sp.
-
 JD6.5, halophilic bacterium
-

Reaction

Reaction Comment Organism Reaction ID
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride the enzyme exhibits stereoselectivity toward the hydrolysis of chiral substrates with a preference for the S-P enantiomers Alteromonas sp.
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p-nitrophenyltriesters Alteromonas sp. ?
-
 ?
O-cyclohexylmethylphosphonofluoridate + H2O i.e. GF Alteromonas sp. ?
-
 ?
paraoxon + H2O i.e. diethyl-4-nitrophenyl phosphate, poor substrate Alteromonas sp. diethylphosphate + 4-nitrophenol
-
 ?
paraoxon + H2O substrate are also 16 paraoxon analogs Alteromonas sp. diethylphosphate + 4-nitrophenol
-
 ?
sarin + H2O i.e. O-isopropylmethylphosphonofluoridate Alteromonas sp. ?
-
 ?
soman + H2O i.e. O-pinacoyl methyl phosphonofluoridates Alteromonas sp. ?
-
 ?