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Literature summary for 3.1.6.12 extracted from

  • Bhattacharyya, S.; Solakyildirim, K.; Zhang, Z.; Chen, M.L.; Linhardt, R.J.; Tobacman, J.K.
    Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate (2010), Am. J. Respir. Cell Mol. Biol., 42, 51-61.
    View publication on PubMed
Search for more literature for 3.1.6.12

Protein Variants

Protein Variants Comment Organism
additional information ASB silencing in IB3-1 and C38 bronchial epithelial cell lines and in primary bronchial epithelial cells, leading to reduced ASB activity, chondroitin 4-sulfate content, and increased interleukin-8 content associated to the cell membranes instead of secreted. Neutrophil attraction to the cell lysate is increased in ABS silencing, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane
-
 Homo sapiens
-
-
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C38 cell
-
 Homo sapiens
-
epithelial cell bronchial Homo sapiens
-
IB3-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl sulfate + H2O
-
 Homo sapiens 4-methylumbelliferone + sulfate
-
 ?

Synonyms

Synonyms Comment Organism
arylsulfatase B
-
 Homo sapiens
ASB
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function ASB and chondroitin 4-sulafte are involved in regulation of interleukin-8 secretion Homo sapiens