Protein Variants | Comment | Organism |
---|---|---|
K405R | mutant cannot be acetylated, reduced activity compared to acetylated wild-type protein. K405R mutant expressing cancer cells show reduced G1/S transition and slower proliferation compared to wildtype | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | SAMHD1 is acetylated at residue K405 in vitro and in vivo by acetylatransferase arrest defective protein ARD1. Acetylated SAMHD1 wildtype proteins have enhanced dNTPase activity in vitro. SAMHD1 acetylation levels are strongest during the G1 phase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocarcinoma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |