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Literature summary for 3.1.4.53 extracted from

  • Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
    Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases (2015), Eur. J. Pharmacol., 746, 14-21 .
    View publication on PubMed
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Mus musculus
3-isobutyl-1-methylxanthine
-
 Rattus norvegicus
carboxyamidotriazole non-selective inhibition Mus musculus
carboxyamidotriazole non-selective inhibition Rattus norvegicus
rolipram
-
 Mus musculus
rolipram
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Mus musculus
-
 5'-AMP
-
 ?
3',5'-cAMP + H2O Rattus norvegicus
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
L-1210 cell
-
 Mus musculus
-
Lewis lung carcinoma cell
-
 Mus musculus
-
lung
-
 Mus musculus
-
lymphocytic leukemia cell
-
 Mus musculus
-
peritoneal macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
adenosine 3',5'-cyclicmonophosphate-specific PDE
-
 Mus musculus
adenosine 3',5'-cyclicmonophosphate-specific PDE
-
 Rattus norvegicus
cAMP-PDE
-
 Mus musculus
cAMP-PDE
-
 Rattus norvegicus
cAMP-phosphodiesterase
-
 Mus musculus
cAMP-phosphodiesterase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000131
-
 enzyme from lung, at pH 8.0 and 30°C Mus musculus rolipram
0.0000149
-
 enzyme from RAW264.7 cells, at pH 8.0 and 30°C Mus musculus rolipram
0.0000188
-
 enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C Mus musculus rolipram
0.0000943
-
 enzyme from brain, at pH 8.0 and 30°C Rattus norvegicus rolipram
0.0000945
-
 enzyme from peritoneal macrophage, at pH 8.0 and 30°C Mus musculus rolipram
0.00159
-
 enzyme from peritoneal macrophage, at pH 8.0 and 30°C Mus musculus carboxyamidotriazole
0.00509
-
 enzyme from lung, at pH 8.0 and 30°C Mus musculus carboxyamidotriazole
0.00562
-
 enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C Mus musculus carboxyamidotriazole
0.00789
-
 enzyme from L1210 cells, at pH 8.0 and 30°C Mus musculus carboxyamidotriazole
0.0112
-
 enzyme from brain, at pH 8.0 and 30°C Rattus norvegicus carboxyamidotriazole
0.0262
-
 enzyme from RAW264.7 cells, at pH 8.0 and 30°C Mus musculus carboxyamidotriazole