Cloned (Comment) | Organism |
---|---|
cloned and expressed in Sf9 cells with recombinant baculovirus infection | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RS-25344 | phosphorylation of PDE-4D3 increases the sensitivity of the enzyme to inhibition by RS-25344 about 100fold | Homo sapiens | |
RS-33793 | phosphorylation of PDE-4D3 increases the sensitivity of the enzyme to inhibition by RS-33793 about 330fold | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the concentration-response curve for Mg2+ is biphasic and ranges from 0.1 to 100 mM. Phosphorylation of PDE-4D3 by protein kinase A produces a monophasic Mg2+ response curve | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of PDE-4D3 by protein kinase A produces a monophasic Mg2+ response curve. Phosphorylation of PDE-4D3 increased the sensitivity of the enzyme to inhibition by RS-25344 (about 100fold) and RS-33793 (about 330fold). Phosphorylation of PDE-4D3 induces an apparent conformation change that increases maximum velocity and sensitivity to inhibition by some analogues of nitraquazone | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 3',5'-cyclic phosphate + H2O | the enzyme is specific for cAMP | Homo sapiens | adenosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE-4D3 | - |
Homo sapiens |