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Literature summary for 3.1.4.53 extracted from
- Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse (2001), Biochim. Biophys. Acta, 1518, 27-35.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diazepam | - |
Mus musculus |  |
| isobutylmethylxanthine | 0.1 mM, 14% inhibition; 0.1 mM, 32% inhibition | Mus musculus | |
| Milrinone | 0.1 mM, 93% inhibition | Mus musculus | |
| Ro 20-1724 | 0.1 mM, 12% inhibition; 0.1 mM, 4% inhibition | Mus musculus | |
| rolipram | 0.1 mM, 4% inhibition; 0.1 mM, 7% inhibition | Mus musculus | |
| zaprinast | 0.1 mM, 67% inhibition; 0.1 mM, 72% inhibition | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
| 0.0092 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 83000 | - |
x * 83000, SDS-PAGE | Mus musculus |
| 93000 | - |
x * 93000, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O89084 | - |
- |
| Mus musculus | Q9QXI7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine 3',5'-cyclic phosphate + H2O | - |
Mus musculus | adenosine 5'-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 83000, SDS-PAGE | Mus musculus |
| ? | x * 93000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE4A1 | - |
Mus musculus |
| PDE4B3 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0183 | - |
diazepam | - |
Mus musculus | |
| 0.0493 | - |
diazepam | - |
Mus musculus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00017 | - |
- |
Mus musculus | rolipram | |
| 0.0011 | - |
- |
Mus musculus | rolipram | |
| 0.0094 | - |
- |
Mus musculus | diazepam | |
| 0.043 | - |
- |
Mus musculus | diazepam | |
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