Literature summary for 3.1.3.B4 extracted from

Cheong, F.Y.; Sharma, V.; Blagoveshchenskaya, A.; Oorschot, V.M.; Brankatschk, B.; Klumperman, J.; Freeze, H.H.; Mayinger, P.
Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity (2010), Traffic, 11, 1180-1190.

Search for more literature for 3.1.3.B4

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of GFP-tagged SAC1, which is distributed throughout the Golgi complex, but is virtually absent from trans-Golgi network membranes, in HeLa cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	majority of SAC1 translocates from the Golgi to the endoplasmic reticulum when quiescent cells are stimulated by growth factors	Homo sapiens	5783	-
Golgi apparatus	majority of SAC1 translocates from the Golgi to the endoplasmic reticulum when quiescent cells are stimulated by growth factors	Homo sapiens	5794	-
additional information	a certain proportion of SAC1 remains localized at the Golgi during cell proliferation and colocalized with mannosidase II	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Sac1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	RNAi-mediated knockdown of SAC1 causes changes in Golgi morphology and mislocalization of Golgi enzymes. Enzymes involved in glycan processing, such as mannosidase II and Nacetylglucosamine transferase I, redistribute to aberrant intracellular structures and to the cell surface in SAC1 knockdown cells. SAC1 depletion also induces a unique pattern of Golgi-specific defects in N- and O-linked glycosylation, phenotype, overview. SAC1 knockdown allows alpha2,6 sialyltransferase to more effectively compete against Core 2 transferase	Homo sapiens
physiological function	SAC1 organizes phosphatidylinositol-4-phosphate distribution between the Golgi complex and the trans-Golgi-network, which is instrumental for resident enzyme partitioning and Golgi morphology	Homo sapiens

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Release 2023.1 (January 2023)