Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Sac1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | deletion of SAC1 encoding a PtdIns(4)P phosphatase, increases levels of most sphingolipid species, including sphingoid bases, sphingoid base phosphates, and phytoceramide. Deletion of SAC1 dramatically reduces inositol phosphosphingolipids, which result from the addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p. Deletion of SAC1 decreases PtdIns dramatically in both steady-state and pulse labeling studies, suggesting that the observed effects on sphingolipids may result from modulation of the availability of PtdIns as a substrate for Aur1p | Saccharomyces cerevisiae |