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Literature summary for 3.1.3.75 extracted from

  • Yadav, M.; SimÃao, A.; Narisawa, S.; Huesa, C.; McKee, M.; Farquharson, C.; Millan, J.
    Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: A unified model of the mechanisms of initiation of skeletal calcification (2011), J. Bone Miner. Res., 26, 286-297.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.75

Protein Variants

Protein Variants Comment Organism
additional information generation of phospho1-R74X-null mutant, i.e. Phospho1-/-, mice by N-ethyl-N-nitrosourea mutagenesis Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphocholine + H2O Mus musculus
-
 choline + phosphate
-
 ?
phosphocholine + H2O Mus musculus C57BL/6
-
 choline + phosphate
-
 ?
phosphoethanolamine + H2O Mus musculus
-
 ethanolamine + phosphate
-
 ?
phosphoethanolamine + H2O Mus musculus C57BL/6
-
 ethanolamine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R2H9
-
-
Mus musculus C57BL/6 Q8R2H9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
femur
-
 Mus musculus
-
tibia
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphocholine + H2O
-
 Mus musculus choline + phosphate
-
 ?
phosphocholine + H2O
-
 Mus musculus C57BL/6 choline + phosphate
-
 ?
phosphoethanolamine + H2O
-
 Mus musculus ethanolamine + phosphate
-
 ?
phosphoethanolamine + H2O
-
 Mus musculus C57BL/6 ethanolamine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
More the phosphatase PHOSPHO1 is a member of the haloacid dehalogenase, HAD, superfamily of Mg2+-dependent hydrolases Mus musculus
phosphatase PHOSPHO1
-
 Mus musculus
PHOSPHO1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction both male and female Phospho1-/- mice are smaller than age-matched heterozygous and wild-type controls and exhibit growth retardation, where bones from 1-month-old male mice are shorter, phenotypes, overview Mus musculus
physiological function role of PHOSPHO1 during endochondral ossification, overview Mus musculus