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Literature summary for 3.1.3.66 extracted from
- The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family (1997), J. Biol. Chem., 272, 23859-23864.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Inositol hexakisphosphate | 50% inhibition at 0.05 mM | Homo sapiens |  |
| Inositol hexakisphosphate | 50% inhibition at 0.05 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.028 | - |
D-myo-Inositol 3,4-bisphosphate | - |
Homo sapiens | |
| 0.034 | - |
D-myo-Inositol 1,3,4-trisphosphate | - |
Rattus norvegicus | |
| 0.039 | - |
D-myo-Inositol 3,4-bisphosphate | - |
Rattus norvegicus | |
| 0.046 | - |
D-myo-Inositol 1,3,4-trisphosphate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q96PE3 | inositol polyphosphate 4-phosphatase type II | - |
| Rattus norvegicus | Q9QWG5 | inositol polyphosphate 4-phosphatase type II | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | - |
? | |
| 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O | - |
Rattus norvegicus | 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | - |
? | |
| D-myo-inositol 1,3,4-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,3,4-trisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 3,4-bisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 4-phosphate + phosphate | - |
? | |
| D-myo-inositol 3,4-bisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 4-phosphate + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Homo sapiens |
| 7 | 8 | - |
Rattus norvegicus |
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