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Literature summary for 3.1.3.64 extracted from

  • Pham, H.Q.; Yoshioka, K.; Mohri, H.; Nakata, H.; Aki, S.; Ishimaru, K.; Takuwa, N.; Takuwa, Y.
    MTMR4, a phosphoinositide-specific 3-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways (2018), Genes Cells, 23, 670-687 .
    View publication on PubMed
Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C407S catalytically inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
autophagic vacuole
-
 Homo sapiens
-
-
endosome late endosome Homo sapiens 5768
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
MTMR4
-
 Homo sapiens
myotubularin-related protein 4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MTMR4 knockdown markedly suppresses the motility, fusion, and fission of phosphatidylinositol 3-phosphate-enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes, and enlargement of phosphatidylinositol 3-phosphate-enriched early and late endosomes. In amino acid- and serum-starved cells, MTMR4 knockdown decreases both autophagosomes and autolysosomes and markedly increased phosphatidylinositol 3-phosphate-containing autophagosomes and late endosome. MTMR4 knockdown inhibits the nuclear translocation of starvation stress responsive transcription factor-EB with reduced expression of lysosome-related genes in starved cells Homo sapiens