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Literature summary for 3.1.3.52 extracted from
- Simvastatin increases liver branched-chain alpha-ketoacid dehydrogenase activity in rats fed with low protein diet (2014), Toxicology, 325, 107-114.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| simvastatin | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-ketoacid dehydrogenase | - |
Rattus norvegicus |
| BCKDH | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Simvastatin administration increases BCKDH activity state and stimulates branched-chain amino acids (BCAAs) catabolism in rats fed with the low protein diet In contrast to rats subjected to protein restriction simvastatin has no effect on liver BCKDH activity in rats fed with the standard diet | Rattus norvegicus |
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