Literature summary for 3.1.3.48 extracted from

Pereira, S.; Santos, M.; Leite, J.; Flores, C.; Eisfeld, C.; Buettel, Z.; Mota, R.; Rossi, F.; De Philippis, R.; Gales, L.; Morais-Cabral, J.; Tamagnini, P.
The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803 (2019), MicrobiologyOpen, 8, e00753 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichiachia coli	Synechocystis sp. PCC 6803

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of Wzb to 2.28 A resolution. Wzb has a classical a low molecular weight protein tyrosine phosphatase conformation	Synechocystis sp. PCC 6803

Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp. PCC 6803	Q55535	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2O + O-phospho-L-tyrosyl-[Wzc]	Wzb dephosphorylates protein tyrosine kinase Wzc	Synechocystis sp. PCC 6803	L-tyrosyl-[Wzc] + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
EpsB	-	Synechocystis sp. PCC 6803
Slr0328	-	Synechocystis sp. PCC 6803
Wzb	-	Synechocystis sp. PCC 6803

General Information

General Information	Comment	Organism
physiological function	protein tyrosine kinase Wzc participates in the production of capsular (CPS) and released (RPS) polysaccharides. The phosphorylation state of Wzc is dependent on the activity of phosphatase Wzb. The absence of phosphatase Wzb affects the phosphorylation/dephosphorylation cycles of Wzc, altering released polysaccharides production, and this effect is not replicated when the Y-rich region of Wzc is truncated. The double mutant lacking both Wzc and Wzb activity exhibits 18% decrease in capsular polysaccharides and a 23% increase of released polysaccharides	Synechocystis sp. PCC 6803

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Release 2023.1 (January 2023)