Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DTT | highly activating at 2 mM | Setaria cervi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-Cyclohexanedione | 40% inhibition at 1 mM | Setaria cervi | |
1-ethyl-3-dimethylaminopropyl carbodiimide | 90% inhibition at 25 mM | Setaria cervi | |
4-hydroxymercuribenzoate | 62% inhibition at 2.5 mM | Setaria cervi | |
Acetylsalicylic acid | 80% inhibition at 0.2 mM | Setaria cervi | |
Ag+ | 62% inhibition at 2.5 mM | Setaria cervi | |
Ammonium molybdate | 98% inhibition at 2 mM | Setaria cervi | |
cantharidin | 17% inhibition at 1 mM | Setaria cervi | |
diethylcarbamazine | 12% inhibition at 0.2 mM | Setaria cervi | |
diethyldicarbonate | 7% inhibition at 1 mM | Setaria cervi | |
EDTA | 51% inhibition at 5 mM | Setaria cervi | |
iodoacetic acid | complete inhibition at 1.0 mM | Setaria cervi | |
L-(+)-Tartrate | 6.5% inhibition at 5 mM | Setaria cervi | |
okadaic acid | 7.5% inhibition at 0.01 mM | Setaria cervi | |
Phenylarsine oxide | a specific PTP inhibitor, 79% inhibition at 1.0 nM | Setaria cervi | |
SK7 | a metal chalcone, complete inhibition at 0.02 mM | Setaria cervi | |
Sodium fluoride | 96% inhibition at 2 mM | Setaria cervi | |
sodium orthovanadate | 99.5% inhibition at 0.05 mM | Setaria cervi | |
Zn2+ | 65.5% inhibition at 2.5 mM | Setaria cervi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Setaria cervi | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates at 2.5 mM | Setaria cervi | |
Mg2+ | activates slightly at 2.5 mM | Setaria cervi | |
Mn2+ | activates at 2.5 mM | Setaria cervi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
gel filtration | Setaria cervi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Setaria cervi | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Setaria cervi | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from adult females by concanavalin A affinity chromatography and cation exchange chromatography to homogeneity | Setaria cervi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | acid phosphatase activity, best tested substrate | Setaria cervi | 4-nitrophenol + phosphate | - |
? | |
additional information | substrate specificity of enzyme PRL, overview. The enzyme also hydrolyzes adenosine diphosphate, fructose 6-phosphate, sodium alpha-naphthyl phosphate, and phosphoenol pyruvate | Setaria cervi | ? | - |
? | |
O-phospho-L-serine + H2O | very low activity with | Setaria cervi | L-serine + phosphate | - |
? | |
O-phospho-L-threonine + H2O | - |
Setaria cervi | L-threonine + phosphate | - |
? | |
O-phospho-L-tyrosine + H2O | - |
Setaria cervi | L-tyrosine + phosphate | - |
? | |
[a protein]-tyrosine phosphate + H2O | - |
Setaria cervi | [a protein]-tyrosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 21000, SDS-PAGE, 1 * 20527, mass spectrometry | Setaria cervi |
Synonyms | Comment | Organism |
---|---|---|
acid phosphatase activity | - |
Setaria cervi |
PRL | - |
Setaria cervi |
protein tyrosine phosphatase | - |
Setaria cervi |
PTP | - |
Setaria cervi |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Setaria cervi |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
80 | activity range, profile overview, maximal activity at 37°C | Setaria cervi |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
the enzyme is almost denatured at 60°C | Setaria cervi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Setaria cervi |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.5 | 8 | activity range, profile overview, maximal activity at pH 5.5 | Setaria cervi |
Organism | Comment | Expression |
---|---|---|
Setaria cervi | the enzyme is slightly upregulated at oxidative stress generated by a Fe2+/H2O2/ascorbate system | up |
General Information | Comment | Organism |
---|---|---|
additional information | the purified enzyme seems to harbor Cys, His, Asp, and Arg residues in its active site | Setaria cervi |