Application | Comment | Organism |
---|---|---|
medicine | the PTPB1 inhibitor JTT-551 improves glucose metabolism by enhancement of insulin signalling and can be useful in the treatment of type 2 diabetes mellitus | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JTT-551 | i.e. monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl)([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview | Homo sapiens | |
JTT-551 | i.e. monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl)([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview. The inhibitor shows a hypoglycaemic effect in ob/ob mice, overview | Mus musculus | |
JTT-551 | i.e. monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl) ([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview. The inhibitor shows a hypoglycaemic effect in rat L6 cells, overview | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6J mice and male ob/ob mice | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | purified recombinant enzyme | Homo sapiens | - |
L-6 myoblast cell | a skeletal myoblast cell line | Rattus norvegicus | - |
T-lymphocyte | - |
Mus musculus | - |
T-lymphocyte | - |
Homo sapiens | - |
T-lymphocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Mus musculus | 4-nitrophenol + phosphate | - |
? | |
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
4-nitrophenyl phosphate + H2O | - |
Rattus norvegicus | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD45 protein tyrosine phosphatase | - |
Mus musculus |
CD45 protein tyrosine phosphatase | - |
Homo sapiens |
CD45 protein tyrosine phosphatase | - |
Rattus norvegicus |
LAR | - |
Mus musculus |
LAR | - |
Homo sapiens |
LAR | - |
Rattus norvegicus |
leucocyte common antigen-related protein tyrosine phosphatase | - |
Mus musculus |
leucocyte common antigen-related protein tyrosine phosphatase | - |
Homo sapiens |
leucocyte common antigen-related protein tyrosine phosphatase | - |
Rattus norvegicus |
protein tyrosine phosphatase 1B | - |
Mus musculus |
protein tyrosine phosphatase 1B | - |
Homo sapiens |
protein tyrosine phosphatase 1B | - |
Rattus norvegicus |
PTP1B | - |
Mus musculus |
PTP1B | - |
Homo sapiens |
PTP1B | - |
Rattus norvegicus |
T-cell protein tyrosine phosphatase | - |
Mus musculus |
T-cell protein tyrosine phosphatase | - |
Homo sapiens |
T-cell protein tyrosine phosphatase | - |
Rattus norvegicus |
TCPTP | - |
Mus musculus |
TCPTP | - |
Homo sapiens |
TCPTP | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00022 | - |
JTT-551 | pH 7.5, 22°C, PTPB1 | Rattus norvegicus | |
0.0093 | - |
JTT-551 | pH 7.5, 22°C, TCPTP | Rattus norvegicus | |
0.03 | - |
JTT-551 | above, pH 7.5, 22°C, CD45 and LAR | Rattus norvegicus |