Protein Variants | Comment | Organism |
---|---|---|
C129S | decreased activity | Homo sapiens |
F28A | decreased activity | Homo sapiens |
K138A | increased activity | Homo sapiens |
L29A | decreased activity | Homo sapiens |
R33A | decreased activity | Homo sapiens |
S35E | decreased activity | Homo sapiens |
S35E/T36E | increased activity | Homo sapiens |
T36E | decreased activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.4 | - |
p-nitrophenyl phosphate | mutant enzyme C129S, at pH 7.0 and 25°C | Homo sapiens | |
2.4 | - |
p-nitrophenyl phosphate | mutant enzyme T36E, at pH 7.0 and 25°C | Homo sapiens | |
2.8 | - |
p-nitrophenyl phosphate | mutant enzyme K138A, at pH 7.0 and 25°C | Homo sapiens | |
3.8 | - |
p-nitrophenyl phosphate | mutant enzyme R33A, at pH 7.0 and 25°C | Homo sapiens | |
3.9 | - |
p-nitrophenyl phosphate | mutant enzyme L29A, at pH 7.0 and 25°C | Homo sapiens | |
4 | - |
p-nitrophenyl phosphate | mutant enzyme F28A, at pH 7.0 and 25°C | Homo sapiens | |
4.2 | - |
p-nitrophenyl phosphate | wild type enzyme, at pH 7.0 and 25°C | Homo sapiens | |
4.5 | - |
p-nitrophenyl phosphate | mutant enzyme S35E, at pH 7.0 and 25°C | Homo sapiens | |
6.9 | - |
p-nitrophenyl phosphate | mutant enzyme S35E/T36E, at pH 7.0 and 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? | |
phosphorylated Src protein + H2O | - |
Homo sapiens | Src protein + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lymphoid-specific tyrosine phosphatase | - |
Homo sapiens |
LyP | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.37 | - |
p-nitrophenyl phosphate | mutant enzyme T36E, at pH 7.0 and 25°C | Homo sapiens | |
0.56 | - |
p-nitrophenyl phosphate | mutant enzyme L29A, at pH 7.0 and 25°C | Homo sapiens | |
0.59 | - |
p-nitrophenyl phosphate | mutant enzyme S35E, at pH 7.0 and 25°C | Homo sapiens | |
0.61 | - |
p-nitrophenyl phosphate | mutant enzyme R33A, at pH 7.0 and 25°C | Homo sapiens | |
0.67 | - |
p-nitrophenyl phosphate | mutant enzyme F28A, at pH 7.0 and 25°C | Homo sapiens | |
0.7 | - |
p-nitrophenyl phosphate | wild type enzyme, at pH 7.0 and 25°C | Homo sapiens | |
0.73 | - |
p-nitrophenyl phosphate | mutant enzyme C129S, at pH 7.0 and 25°C | Homo sapiens | |
0.81 | - |
p-nitrophenyl phosphate | mutant enzyme K138A, at pH 7.0 and 25°C | Homo sapiens | |
0.89 | - |
p-nitrophenyl phosphate | mutant enzyme S35E/T36E, at pH 7.0 and 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0046 | - |
- |
Homo sapiens | 6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid |