Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | Mus musculus | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | Homo sapiens | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | monoacylglycerol + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | Mus musculus | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | sphingosine + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | Homo sapiens | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | sphingosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14495 | - |
- |
Mus musculus | Q99JY8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens | monoacylglycerol + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine-1-phosphate + H2O | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase 3 | - |
Mus musculus |
lipid phosphate phosphatase 3 | - |
Homo sapiens |
LPP3 | - |
Mus musculus |
LPP3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells and stimulates smooth muscle cell proliferation. Hepatocyte-specific Plpp3 deficiency, by modulating the plasma lipidome, exacerbates atherosclerosis development in Apoe-/-x01mice | Mus musculus |
malfunction | LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells, and stimulates smooth muscle cell proliferation | Homo sapiens |
physiological function | LPP3 activity is crucial for vascular and heart development | Mus musculus |
physiological function | LPP3 activity is crucial for vascular and heart development | Homo sapiens |
physiological function | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Mus musculus |
physiological function | LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids | Homo sapiens |