Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Salmonella enterica | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | - |
serovar typhimurium | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Salmonella enterica | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide phosphatase | - |
Salmonella enterica |
SopB | - |
Salmonella enterica |
General Information | Comment | Organism |
---|---|---|
malfunction | inducible reduction of negative charge rescues DELTAsopB bacteria-containing Salmonella-containing vacuoles from fusion with lysosomes | Salmonella enterica |
additional information | Salmonella typhimurium uses a membrane-charge based mechanism to control Salmonella-containing vacuole maturation | Salmonella enterica |
physiological function | the bacterial phosphoinositide phosphatase SopB is a phosphoinositide phosphatase that, by dephosphorylation of phosphatidylinositol-4,5-bisphosphate at the plasma membrane, contributes to invasion and nascent Salmonella-containing vacuole biogenesis, and controls membrane surface charge of nascent Salmonella-containing vacuoles by reducing levels of negatively charged lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine. This SopB activity results in dissociation of a number of hostcell endocytic trafficking proteins from this compartment and inhibits Salmonella-containing vacuole-lysosome fusion, mechanism, overview. SopB is required for efficient sealing of the Salmonella-containing vacuole membrane during invasion. SopB alters Rab protein recruitment to phagosomes | Salmonella enterica |