Literature summary for 3.1.3.36 extracted from

Johenning, F.W.; Wenk, M.R.; Uhlen, P.; Degray, B.; Lee, E.; De Camilli, P.; Ehrlich, B.E.
InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 (2004), Biochem. J., 382, 687-694.

Search for more literature for 3.1.3.36

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence detremination and analysis, expression of GFP-tagged synaptojanin-1 in CHO cells	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens
additional information	the enzyme reduces the Ca2+ flux in the cell	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	Homo sapiens	synaptojanin-1 regulates of turnover of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pool involved Ca2+ signalling and in clathrin and actin dynamics at the cell surface, SJ-1 attenuates the oscillations of Ca2+ induced by ATP and the catalytic domain of its 5-Pase domain mimicking the effect, overview	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	synaptojanin-1 regulates of turnover of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pool involved Ca2+ signalling and in clathrin and actin dynamics at the cell surface, SJ-1 attenuates the oscillations of Ca2+ induced by ATP and the catalytic domain of its 5-Pase domain mimicking the effect, overview	Homo sapiens	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
7-nitrobenz-2-oxa-1,3-diazole 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	fluorescence-labeled substrate	Homo sapiens	7-nitrobenz-2-oxa-1,3-diazole 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphoinositide phosphatase	-	Homo sapiens
PtdIns(4,5)P2 phosphatase	-	Homo sapiens
SJ-1	-	Homo sapiens
synaptojanin-1	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)