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Literature summary for 3.1.3.16 extracted from

  • Calvayrac, O.; Pradines, A.; Favre, G.
    RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers (2018), Small GTPases, 9, 339-344 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
RHOB GTPase RAS-related small GTPase RHOB binds and activates the tumor suppressor PP2A, RHOB binds to the catalytic subunit of PP2A Homo sapiens

Application

Application Comment Organism
diagnostics dephosphorylation of AKT by the PP2A phosphatase is known to be an important mechanism in determining the cellular levels of phosphorylated AKT Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[AKT1 protein]-serine/threonine phosphate + H2O Homo sapiens
-
 [AKT1 protein]-serine/threonine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[AKT1 protein]-serine/threonine phosphate + H2O
-
 Homo sapiens [AKT1 protein]-serine/threonine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
serine/threonine protein phosphatase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction decreased PP2A activity promotes cellular transformation, and numerous studies have highlighted a tumor suppressor role for PP2A. PP2A loss-of-function occurs by molecular mechanisms such as mutations of the PP2A subunits, phosphorylation and methylation of PP2A-C, deregulation of the expression of the regulatory subunits or endogenous PP2A inhibitors. PP2A inhibition impairs double strand break (DSB) repair by homologous recombination Homo sapiens
additional information PP2A is a trimeric holoenzyme containing a scaffold subunit (PP2A-A), a catalytic subunit (PP2A-C), and a regulatory B subunit. Four B subunit families have been described: B (B55/PR55), B0 (B56/PR61), B00 (PR48/72/ 130) and B000 (PR93/110). The type of B subunit bound to the PP2A dimer determines both the substrate specificity and the cellular localization of the PP2A holoenzyme complex Homo sapiens
physiological function protein phosphatase PP2A controls a variety of cellular functions through a broad spectrum of substrates, including cell cycle regulation, apoptosis, mitosis and DNA damage repair, and controls major signaling pathways including the MAPK and AKT pathways. The RAS-related small GTPase RHOB positively regulates PP2A, one of the major cellular serine-threonine phosphatases, by recruiting its regulatory subunit B55. Role of the RHOB/PP2A/AKT1/RAC1 pathway in relation to mesenchymal migration and invasion in lung cancer, overview. RHOB binds and activates the tumor suppressor PP2A, RHOB binds to the catalytic subunit of PP2A. PP2A is known to play a prevalent role in dephosphorylating histone 2A (gH2AX) after treatment with the selective topoisomerase I inhibitor camptothecin Homo sapiens