Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated histone deacetylase 3 + H2O | Homo sapiens | dephosphorylation at Ser424, PP4 negatively regulates the activity of histone deacetylase 3 by direct protein-protein interaction also involving the so-repressors N-CoR and SMRT | histone deacetylase 3 + phosphate | - |
? | |
phosphorylated histone deacetylase 3 + H2O | Homo sapiens | PP4 regulates histone deacetylase 3, HDAC3, activity by dephosphorylation of Ser424, and by direct protein-protein interaction of active PP4 which is complexed with HDAC3 via the N-terminus of the deacetylase, PP4 is the limiting factor and is not saturating in the complex in vivo | histone deacetylase 3 + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated histone deacetylase 3 + H2O | dephosphorylation at Ser424, PP4 negatively regulates the activity of histone deacetylase 3 by direct protein-protein interaction also involving the so-repressors N-CoR and SMRT | Homo sapiens | histone deacetylase 3 + phosphate | - |
? | |
phosphorylated histone deacetylase 3 + H2O | PP4 regulates histone deacetylase 3, HDAC3, activity by dephosphorylation of Ser424, and by direct protein-protein interaction of active PP4 which is complexed with HDAC3 via the N-terminus of the deacetylase, PP4 is the limiting factor and is not saturating in the complex in vivo | Homo sapiens | histone deacetylase 3 + phosphate | - |
? | |
phosphorylated histone deacetylase 3 + H2O | i.e. HDAC3, a class I histone deacetylase, dephosphorylation at Ser424 of the protein kinase CK2 phosphoacceptor site | Homo sapiens | histone deacetylase 3 + phosphate | - |
? | |
phosphorylated histone deacetylase 3 + H2O | PP4 dephosphorylates Ser424 | Homo sapiens | histone deacetylase 3 + phosphate | - |
? | |
RRAS(P)VA + H2O | synthetic substrate | Homo sapiens | RRASVA + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pp4 | - |
Homo sapiens |
protein serine/threonine phosphatase 4 | - |
Homo sapiens |
serine/threonine protein phosphatase 4 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |