Cloned (Comment) | Organism |
---|---|
expressed enzyme-deficient Mus musculus | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
ALPL | - |
Homo sapiens |
strensiq | recombinant enzyme, previously known as asfotase-alfa | Homo sapiens |
tissue nonspecific alkaline phosphatase | - |
Homo sapiens |
TNAP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency diminishes chondrocyte vascular endothelial cell growth factor expression | Homo sapiens |
physiological function | the enzyme influences chondrocyte maturation, apoptosis, and MAPK signaling in a cell autonomous manner. The enzyme is essential for the later stages of endochondral bone development including hypertrophic chondrocyte apoptosis and vascular endothelial cell growth factor-mediated recruitment of blood vessels for replacement of cartilage with bone | Homo sapiens |