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Literature summary for 3.1.26.12 extracted from

  • Shin, E.; Go, H.; Yeom, J.H.; Won, M.; Bae, J.; Han, S.H.; Han, K.; Lee, Y.; Ha, N.C.; Moore, C.J.; Sohlberg, B.; Cohen, S.N.; Lee, K.
    Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain (2008), Genetics, 179, 1871-1879.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.12

Protein Variants

Protein Variants Comment Organism
A326T random mutagenesis, mutation in the DNase I subdomain, the mutant shows no detectable binding to p23 RNA due to a reduction in the substrate-binding ability Escherichia coli
I41N random mutagenesis, mutation in the SI subdomain, the mutant shows no detectable binding to p23 RNA due to a reduction in the substrate-binding ability Escherichia coli
L385P random mutagenesis, mutation in the DNase I subdomain, the mutant shows no detectable binding to p23 RNA due to a reduction in the substrate-binding ability Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BR13 + H2O Escherichia coli endonucleolytic cleavage, BR13 is an oligoribonucleotide that contains the RNase E-cleaved sequence of RNA I ?
-
 ?
additional information Escherichia coli RNase E is an essential Escherichia coli endoribonuclease that plays a major role in the decay and processing of a large fraction of RNAs in the cell, overview ?
-
 ?
p23 RNA + H2O Escherichia coli endonucleolytic cleavage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P21513
-
-

Reaction

Reaction Comment Organism Reaction ID
endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions molecular mechanism, residues A326 and L385 are involved in substrate binding Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BR13 + H2O endonucleolytic cleavage, BR13 is an oligoribonucleotide that contains the RNase E-cleaved sequence of RNA I Escherichia coli ?
-
 ?
additional information RNase E is an essential Escherichia coli endoribonuclease that plays a major role in the decay and processing of a large fraction of RNAs in the cell, overview Escherichia coli ?
-
 ?
p23 RNA + H2O endonucleolytic cleavage Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase E
-
 Escherichia coli