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Literature summary for 3.1.21.5 extracted from

  • Anjum, A.; Brathwaite, K.J.; Aidley, J.; Connerton, P.L.; Cummings, N.J.; Parkhill, J.; Connerton, I.; Bayliss, C.D.
    Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 (2016), Nucleic Acids Res., 44, 4581-4594 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Campylobacter jejuni Q0PC94 motile but non-swarming variant 11168 and a chicken-adapted hypermotile variant CH11168
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Campylobacter jejuni NCTC 11168 Q0PC94 motile but non-swarming variant 11168 and a chicken-adapted hypermotile variant CH11168
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Synonyms

Synonyms Comment Organism
cj0031
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 Campylobacter jejuni

General Information

General Information Comment Organism
physiological function dual role for phase variation of the enzyme as a limiter of phage spread and a regulator of a gene expression. The underlying mechanism of action for the alteration in gene expression is not known and does not appear to involve differential methylation of specific recognition sites by Cj0031. Phase variation of Cj0031, as detected during infections in chickens and mice, produces changes in expression of multiple genes that may lead to phenotypic variation and generation of highly differentiated variants with differing capabilities of adaptation to diverse niches Campylobacter jejuni