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Literature summary for 3.1.21.4 extracted from
- Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases (2015), Bioorg. Med. Chem., 23, 6885-6890.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing F5dC + H2O | Bacillus subtilis | perfectly hydrolyzes the DNA containing 5-fluoro-dC | ? | - |
? |  |
| DNA containing F5dU + H2O | Bacillus subtilis | perfectly hydrolyzes the DNA containing 5-fluoro-dU | ? | - |
? | |
| additional information | Bacillus subtilis | no hydrolysis of DNA containing 5-methyl-dC | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acetobacter pasteurianus | O52703 | - |
- |
| Acidithiobacillus ferrooxidans | Q4GZN8 | - |
- |
| Bacillus amyloliquefaciens | P23940 | - |
- |
| Bacillus subtilis | Q45488 | - |
- |
| Dolichospermum flos-aquae | E3VX87 | - |
- |
| Dolichospermum flos-aquae CCAP 1403/13F | E3VX87 | - |
- |
| Escherichia coli | P00642 | - |
- |
| Gordonia rubripertincta | O85489 | - |
- |
| Haemophilus influenzae | P43870 | - |
- |
| Haemophilus influenzae ATCC 51907 | P43870 | - |
- |
| Klebsiella pneumoniae | P25237 | - |
- |
| Proteus hauseri | P23657 | - |
- |
| Providencia stuartii | P00640 | - |
- |
| Pseudogemmobacter blasticus | Q6SA27 | - |
- |
| Pyrococcus sp. GI-H | O93646 | - |
- |
| Streptomyces caespitosus | O52691 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Acidithiobacillus ferrooxidans | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Dolichospermum flos-aquae | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Acetobacter pasteurianus | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Bacillus amyloliquefaciens | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Escherichia coli | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Haemophilus influenzae | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Klebsiella pneumoniae | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Gordonia rubripertincta | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Pyrococcus sp. GI-H | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Providencia stuartii | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Proteus hauseri | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Pseudogemmobacter blasticus | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Streptomyces caespitosus | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Haemophilus influenzae ATCC 51907 | ? | - |
? | |
| DNA containing 5-fluoro-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Dolichospermum flos-aquae CCAP 1403/13F | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Acidithiobacillus ferrooxidans | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | hydrolyzes the DNA containing F5dU | Dolichospermum flos-aquae | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Acetobacter pasteurianus | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Bacillus amyloliquefaciens | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | hydrolyzes the DNA containing F5dU | Escherichia coli | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Haemophilus influenzae | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Klebsiella pneumoniae | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dU | Gordonia rubripertincta | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dU | Pyrococcus sp. GI-H | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dU | Proteus hauseri | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dU | Pseudogemmobacter blasticus | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | hydrolyzes the DNA containing 5-fluoro-dU | Streptomyces caespitosus | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | perfectly hydrolyzes the DNA containing F5dU | Haemophilus influenzae ATCC 51907 | ? | - |
? | |
| DNA containing 5-fluoro-dU + H2O | hydrolyzes the DNA containing F5dU | Dolichospermum flos-aquae CCAP 1403/13F | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | hydrolyzes the DNA containing F5dC | Escherichia coli | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | hydrolyzes the DNA containing F5dC | Haemophilus influenzae | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | perfectly hydrolyzes the DNA containing F5dC | Klebsiella pneumoniae | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | perfectly hydrolyzes the DNA containing 5-methyl-dC | Proteus hauseri | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Pseudogemmobacter blasticus | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | perfectly hydrolyzes the DNA containing 5-methyl-dC | Streptomyces caespitosus | ? | - |
? | |
| DNA containing 5-methyl-dC + H2O | hydrolyzes the DNA containing F5dC | Haemophilus influenzae ATCC 51907 | ? | - |
? | |
| DNA containing F5dC + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dC | Bacillus subtilis | ? | - |
? | |
| DNA containing F5dU + H2O | perfectly hydrolyzes the DNA containing 5-fluoro-dU | Bacillus subtilis | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Bacillus subtilis | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Acidithiobacillus ferrooxidans | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Dolichospermum flos-aquae | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Acetobacter pasteurianus | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Bacillus amyloliquefaciens | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Gordonia rubripertincta | ? | - |
? | |
| additional information | no hydrolysis DNA containing 5-methy-dC | Pyrococcus sp. GI-H | ? | - |
? | |
| additional information | no hydrolysis DNA containing 5-methyl-dC or 5-fluoro-dU | Providencia stuartii | ? | - |
? | |
| additional information | no hydrolysis of DNA containing 5-methyl-dC | Dolichospermum flos-aquae CCAP 1403/13F | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AfeI | - |
Acidithiobacillus ferrooxidans |
| AflII | - |
Dolichospermum flos-aquae |
| aflIIR | - |
Dolichospermum flos-aquae |
| ApaLI | - |
Acetobacter pasteurianus |
| apaLIR | - |
Acetobacter pasteurianus |
| BamHI | - |
Bacillus amyloliquefaciens |
| bamHIR | - |
Bacillus amyloliquefaciens |
| BglII | - |
Bacillus subtilis |
| bglIIR | - |
Bacillus subtilis |
| EcoRI | - |
Escherichia coli |
| ecoRIR | - |
Escherichia coli |
| HindIII | - |
Haemophilus influenzae |
| hindIIIR | - |
Haemophilus influenzae |
| KpnI | - |
Klebsiella pneumoniae |
| KpnIR | - |
Klebsiella pneumoniae |
| NcoI | - |
Gordonia rubripertincta |
| ncoIR | - |
Gordonia rubripertincta |
| PspGI | - |
Pyrococcus sp. GI-H |
| PstI | - |
Providencia stuartii |
| pstIR | - |
Providencia stuartii |
| PvuII | - |
Proteus hauseri |
| RsaI | - |
Pseudogemmobacter blasticus |
| ScaI | - |
Streptomyces caespitosus |
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