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Literature summary for 3.1.21.4 extracted from
- The type II restriction endonuclease MvaI has dual specificity (2010), Nucleic Acids Res., 38, 8231-8238.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Kocuria varians | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | MvaI restriction endonuclease cuts 5'-CC-/-AGG-3'/5'-CC-/-TGG-3' sites. N4-methylation of the inner cytosines, Cm4CAGG/Cm4CTGG, protects the site against MvaI cleavage. MvaI nicks the G-strand of the related sequence (CCGGG/CCCGG, BcnI site) if the inner cytosines are C5-methylated: Cm5C-/-GGG/CCm5CGG. At M.SssI-methylated SmaI sites, of M.SssI DNA methyltransferase, where two oppositely oriented methylated BcnI sites partially overlap, double-nicking leads to double-strand cleavage (CCm5C-/-GGG/CCm5C-/-GGG) generating fragments with blunt ends | Kocuria varians | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MvaI | - |
Kocuria varians |
| type II restriction endonuclease | - |
Kocuria varians |
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