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Literature summary for 3.1.21.4 extracted from

  • Zahran, M.; Berezniak, T.; Imhof, P.; Smith, J.C.
    Role of magnesium ions in DNA recognition by the EcoRV restriction endonuclease (2011), FEBS Lett., 585, 2739-2743.
    View publication on PubMed
Search for more literature for 3.1.21.4

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ EcoRV binds two magnesium ions in the active site. One of these ions, Mg2+A, binds to the phosphate group where the cleavage occurs and is required for catalysis. The other, Mg2+B, is crucial for achieving a tightly bound protein-DNA complex and stabilizing a conformation that allows cleavage, structure analysis, molecular dynamics simulations, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli schematic view of the hydrogen-bond interactions of the DNA with each subunit of the protein for the 2TA and 1TA complexes, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information schematic view of the hydrogen-bond interactions of the DNA with each subunit of the protein for the 2TA and 1TA complexes, overview Escherichia coli ?
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 ?

Synonyms

Synonyms Comment Organism
EcoRV
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 Escherichia coli
restriction endonuclease EcoRV
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 Escherichia coli
type II restriction endonuclease
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 Escherichia coli