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Literature summary for 3.1.2.12 extracted from

  • Tuin, A.W.; Mol, M.A.; van den Berg, R.M.; Fidder, A.; van der Marel, G.A.; Overkleeft, H.S.; Noort, D.
    Activity-based protein profiling reveals broad reactivity of the nerve agent sarin (2009), Chem. Res. Toxicol., 22, 683-689.
    View publication on PubMed
Search for more literature for 3.1.2.12

Inhibitors

Inhibitors Comment Organism Structure
11-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)undecyl methylphosphonofluoridoate
-
 Homo sapiens
sarin strong inhibition at 0.0008 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information esterase D/S-formylglutathione hydrolase plays a key role in glutathione-dependent detoxification of endogenously formed formaldehyde as well as in hydrolysis of various xenobiotics Homo sapiens ?
-
 ?
S-formylglutathione + H2O
-
 Homo sapiens glutathione + formate
-
 ?

Synonyms

Synonyms Comment Organism
esterase D/S-formylglutathione hydrolase
-
 Homo sapiens