Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Moloney murine leukemia virus | the enzyme is essential for retroviral replication | ? | - |
? | |
additional information | Human immunodeficiency virus 1 | the enzyme is essential for retroviral replication | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Moloney murine leukemia virus | - |
i.e. M-MuLV | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid | the selection of 5'-end-directed cleavage sites by the retroviral RNase H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5'-end | Moloney murine leukemia virus | |
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid | the selection of 5'-end-directed cleavage sites by the retroviral RNase H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5'-end | Human immunodeficiency virus 1 |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Moloney murine leukemia virus | - |
commercial preparation | recombinant enzyme | Human immunodeficiency virus 1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid + H2O | cleavage site recognition and specificity, mechanism, in vitro synthesis of substrates, overview | Moloney murine leukemia virus | ? | - |
? | |
DNA-RNA hybrid + H2O | cleavage site recognition and specificity, mechanism, in vitro synthesis of substrates, overview | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the enzyme is essential for retroviral replication | Moloney murine leukemia virus | ? | - |
? | |
additional information | the enzyme is essential for retroviral replication | Human immunodeficiency virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme is part of the viral reverse transcriptase | Moloney murine leukemia virus |
More | the enzyme is part of the viral reverse transcriptase | Human immunodeficiency virus 1 |
retroviral RNase H | - |
Moloney murine leukemia virus |
retroviral RNase H | - |
Human immunodeficiency virus 1 |