Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-azido-3'-deoxythymidine 5'-phosphate | more sensitive to inhibition with poly(rGdC) than with poly(rAdT) as substrate. Competitive inhibitor with respect to substrate in Mn2+, uncompetitive inhibitor in Mg2+ | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in Mg2+, hydrolysis of poly(rAdT) appears to be solely endonucleolytic. In Mn2+, hydrolysis of poly(rAdT) is both endonucleolytic and exonucleolytic. With poly(rGdC) as substrate, hydrolysis is both endonucleolytic and exonucleolytic in either Mg2+ or Mn2+ | Human immunodeficiency virus 1 | ? | - |
? | |
RNA-DNA hybrid + H2O | poly(rGdC) | Human immunodeficiency virus 1 | ribonucleotide 5'-phosphomonoester | - |
? |