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Literature summary for 3.1.1.64 extracted from

  • Redmond, T.M.; Poliakov, E.; Yu, S.; Tsai, J.Y.; Lu, Z.; Gentleman, S.
    Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle (2005), Proc. Natl. Acad. Sci. USA, 102, 13658-13663.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.64

Cloned(Commentary)

Cloned (Comment) Organism
expressed in 293-F cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A132T 50% activity compared to the wild type enzyme Homo sapiens
A434V 55% activity compared to the wild type enzyme Homo sapiens
C231S 55% activity compared to the wild type enzyme Homo sapiens
C329S 26% activity compared to the wild type enzyme Homo sapiens
C329S/C330S less than 2% activity compared to the wild type enzyme Homo sapiens
C330T 83% activity compared to the wild type enzyme Homo sapiens
C330Y less than 2% activity compared to the wild type enzyme Homo sapiens
E417A less than 2% activity compared to the wild type enzyme Homo sapiens
E417Q less than 2% activity compared to the wild type enzyme Homo sapiens
G40S less than 2% activity compared to the wild type enzyme Homo sapiens
G528V less than 2% activity compared to the wild type enzyme Homo sapiens
H180A less than 2% activity compared to the wild type enzyme Homo sapiens
H182A 10% activity compared to the wild type enzyme Homo sapiens
H182Y 10% activity compared to the wild type enzyme Homo sapiens
H241A less than 2% activity compared to the wild type enzyme Homo sapiens
H313A less than 2% activity compared to the wild type enzyme Homo sapiens
H527A less than 2% activity compared to the wild type enzyme Homo sapiens
H68A less than 2% activity compared to the wild type enzyme Homo sapiens
H68Y less than 2% activity compared to the wild type enzyme Homo sapiens
K294T 16% activity compared to the wild type enzyme Homo sapiens
R44Q less than 2% activity compared to the wild type enzyme Homo sapiens
Y368F 56% activity compared to the wild type enzyme Homo sapiens
Y368H less than 3% activity compared to the wild type enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dipyridyl
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
 x * 61000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinyl ester + H2O
-
 Homo sapiens 11-cis-retinol + a fatty acid
-
 ?

Subunits

Subunits Comment Organism
? x * 61000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Rpe65
-
 Homo sapiens