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Literature summary for 3.1.1.55 extracted from
- Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545 (2010), Biochem. Pharmacol., 79, 784-791.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl salicylate + H2O | fatty acid-free human albumin and human plasma are treated with aspirin for 5 min-24 h. Acetylated residues are identified by LC/MS/MS and MALDI-TOF/TOF mass spectrometry of tryptic peptides. Treatment with 0.3 mM aspirin results in acetylation of Lys-199, Lys-402, Lys-519, and Lys-545. Treatment with 20 mM aspirin results in acetylation of 26 lysines. There is no acetylation of Tyr-411, under any conditions. Acetylated lysine is stable for at least 21 days at pH 7.4, 37°C | Homo sapiens | salicylate + acetate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspirin esterase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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