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Literature summary for 3.1.1.4 extracted from
- Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2. Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability (2017), Eur. J. Med. Chem., 125, 1107-1114 .
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | the enzyme is an attractive target for the development of anti-inflammatory drugs | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens |  |
| 3-(2-methylpropanoyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(2-methylpropanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(3-carboxypropanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(4-hydroxybutanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(4-methoxybutanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(5-carboxypentanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(6-hydroxyhexanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-(6-methoxyhexanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-butanoyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
| 3-hexanoyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P47712 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cPLA2alpha | - |
Homo sapiens |
| phospholipase A2alpha | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-butanoyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2-methylpropanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(2-methylpropanoyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid | |
| 0.000015 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-methoxybutanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-carboxypentanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000023 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-hydroxybutanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000031 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-hydroxyhexanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000049 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-methoxyhexanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.000071 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hexanoyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.00021 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(3-carboxypropanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
| 0.00035 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | key enzyme in the biosynthesis of pro-inflammatory lipid mediators | Homo sapiens |
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