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Literature summary for 3.1.1.4 extracted from

  • Duvernay, M.T.; Matafonov, A.; Lindsley, C.W.; Hamm, H.E.
    Platelet lipidomic profiling novel insight into cytosolic phospholipase A2alpha activity and its role in human platelet activation (2015), Biochemistry, 54, 5578-5588 .
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
giripladib i.e. Wyeth-2, the inhibition of phospholipase A2alpha reduces platelet adhesion and accumulation on collagen, it inhibits cPLA2alpha-mediated release of arachidonic acid from glycerophospholipid sources; inhibitor, reduces platelet adhesion and accumulation on collagen. Giripladib differentially affects P-selectin expression and GPIIbIIIa activation depending on the agonist employed. The levels of PAR4- and GPVI-mediated platelet activation are significantly reduced Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P47712
-
-
Homo sapiens W0FXB0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
cPLA2alpha
-
 Homo sapiens
phospholipase A2alpha
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function phosphatidylinositol is a substrate of cPLA2alpha in the human platelet and the majority of phosphatidylinositol lost during thrombin stimulation is a result of cPLA2alpha activity Homo sapiens
physiological function significant role of cPLA2alpha activity in the hemostatic response of blood, major role of cPLA2alpha activity in platelet function Homo sapiens