Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cPLA2 is activated by phosphorylation involving the cellular prion protein, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | prion infection greatly increased the phosphorylation of cPLA2 leading to increased activation of the PLA2 pathway | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Mus musculus | - |
additional information | the enzyme co-precipitates with the alternatively folded cellular prion protein isoform PrPSc | Mus musculus | - |
neuron | primary cortical neurons | Mus musculus | - |
neuronal cell | - |
Mus musculus | - |
ScGT1 cell | a hypothalamic neuronal cell line | Mus musculus | - |
ScN2a cell | a hypothalamic neuronal cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cPLA2 | - |
Mus musculus |
cytoplasmic phospholipase A2 | - |
Mus musculus |