Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol | MJ33, competitive inhibitor | Bos taurus | |
3,4-dichloroisocoumarin | - |
Bos taurus | |
3,4-dichloroisocoumarin | - |
Homo sapiens | |
anti-peptide antibody | - |
Bos taurus | |
Diethyl p-nitrophenyl phosphate | - |
Bos taurus | |
Diethyl p-nitrophenyl phosphate | - |
Homo sapiens | |
diisopropyl fluorophosphate | - |
Bos taurus | |
diisopropyl fluorophosphate | - |
Homo sapiens | |
phenylmethylsulfonyl fluoride | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Bos taurus | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
- |
Homo sapiens |
29000 | - |
- |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Homo sapiens | - |
? | - |
? | |
phospholipids + H2O | Bos taurus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
cow | - |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial purification, 176fold | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.027 | - |
acidic iPLA2, substrate: 1-O-hexadecyl-2-arachidonoyl-glycero-3-phosphocholine | Bos taurus |
0.064 | - |
acidic iPLA2, substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine or 1,2-dipalmitoyl-phosphatidylcholine | Bos taurus |
0.065 | - |
acidic iPLA2, substrate: oxidized 1-palmitoyl-2-arachidonylphosphatidylcholine | Bos taurus |
0.08 | - |
acidic iPLA2, pH 4.0, Ca2+-free medium, substrate: 1,2-dipalmitoyl-phosphatidylcholine | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Bos taurus | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O | - |
Bos taurus | 1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid | - |
? | |
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Bos taurus | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
oxidized phosphatidylcholines + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + oxidized fatty acids | - |
? | |
oxidized phosphatidylcholines + H2O | oxidized 1-palmitoyl-2-arachidonoylphosphatidylcholine for substrate | Bos taurus | 1-acylglycerophosphocholine + oxidized fatty acids | - |
? | |
phosphatidylcholine + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + fatty acid | - |
? | |
phosphatidylcholine + H2O | - |
Bos taurus | 1-acylglycerophosphocholine + fatty acid | - |
? | |
phospholipids + H2O | - |
Homo sapiens | ? | - |
? | |
phospholipids + H2O | - |
Bos taurus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | - |
at pH 7.4 or 8.5 the activity of acidic iPLA2 decreased above 97% | Bos taurus |