Cloned (Comment) | Organism |
---|---|
full length human cPLA2, residues 1-749, expressed in E5-CHO-cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | structure of Ca2+-binding site | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Homo sapiens | influence on platelet aggregation | ? | - |
? | |
phospholipids + H2O | Homo sapiens | inflammatory diseases | ? | - |
? | |
phospholipids + H2O | Homo sapiens | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | cPLA2 cleaves selectively arachidonoyl phospholipids | Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O | cPLA2 cleaves selectively arachidonoyl containing phospholipids | Homo sapiens | 1-stearoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
phospholipids + H2O | influence on platelet aggregation | Homo sapiens | ? | - |
? | |
phospholipids + H2O | inflammatory diseases | Homo sapiens | ? | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | cPLA2, no data concerning MW | Homo sapiens |