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Literature summary for 3.1.1.34 extracted from

  • Liu, L.; Heneghan, J.F.; Michael, G.J.; Stanish, L.F.; Egertova, M.; Rittenhouse, A.R.
    L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity (2008), J. Cell. Physiol., 216, 91-100.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
RHC-80267 i.e. 1,6-di(O-(carbamoyl)cyclohexanone oxime)hexane, is a highly selective DAGL inhibitor. It significantly reduces L- and N-current inhibition by the muscarinic agonist oxotremorine-M, Oxo-M, but does not affect their inhibition by exogenous arachidonic acid, currents by Ba2+ or Ca2+. Moreover, voltage-dependent inhibition of N-current by Oxo-M remains in the presence of RHC-80267, indicating selective action on the slow pathway, i.e. the voltage-independent, pertussis-toxin insensitive pathway. RHC-80267 also blocks inhibition of recombinant N-current, but has no effect on native M-current inhibition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 adult male Sprague-Dawley and Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
neuron SCG neurons Rattus norvegicus
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Synonyms

Synonyms Comment Organism
DAG lipase
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 Rattus norvegicus
DAGL
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 Rattus norvegicus
diacylglycerol lipase
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function arachidonic acid signaling requires DAGL in many systems. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity, overview. The signaling pathway mediating L- and N-current inhibition diverges from the pathway initiating M-current inhibition Rattus norvegicus