Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, PKA also phosphorylates the lipase, but does not directly activate it, overview, the changes induced by adipokinetic hormone on the lipid droplets contribute with an approximately 2fold increase to the overall rate of lipolysis | Manduca sexta |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Manduca sexta | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | Manduca sexta | the enzyme is involved in adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta, protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, protein kinase A also phosphorylates the lipase, but does not directly activate it, overview | diacylglycerol + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Manduca sexta | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | protein kinase A phosphorylates the TG-lipase, while it does not directly activate it, but activates the lipid droplet substrate, also increasing enzyme activity that way, overview | Manduca sexta |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fat body | - |
Manduca sexta | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Manduca sexta |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | - |
Manduca sexta | diacylglycerol + a carboxylate | - |
? | |
triacylglycerol + H2O | the enzyme is involved in adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta, protein kinase A phosphorylates and activates the TG-lipase substrate, the lipid droplets, protein kinase A also phosphorylates the lipase, but does not directly activate it, overview | Manduca sexta | diacylglycerol + a carboxylate | - |
? | |
triolein + H2O | - |
Manduca sexta | diolein + oleate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TG-lipase | - |
Manduca sexta |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Manduca sexta |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Manduca sexta |