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Literature summary for 3.1.1.24 extracted from

  • Yeh, W.K.; Ornston, L.N.
    p-Chloromercuribenzoate specifically modifies thiols associated with the active sites of beta-ketoadipate enol-lactone hydrolase and succinyl CoA: beta-ketoadipate CoA transferase (1984), Arch. Microbiol., 138, 102-105.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
3-oxoadipate 50% inhibition at a concentration of 17 mM; i.e. beta-ketoadipate Acinetobacter calcoaceticus
3-oxoadipate 10% inhibition at a concentration of 1 mM; 50% inhibition at a concentration of 10 mM; i.e. beta-ketoadipate Pseudomonas putida
5,5'-dithiobis(2-nitrobenzoic acid) completely inactivated, activity can not be recovered by adding dithiothreitol Pseudomonas putida
additional information not inhibited by adipate and levulinate at a concentration of 20 mM Acinetobacter calcoaceticus
additional information not inhibited by adipate and levulinate at a concentration of 20 mM Pseudomonas putida
p-chloromercuribenzoate
-
 Acinetobacter calcoaceticus
p-chloromercuribenzoate completely inactivated at a concentration of 0.005 mM, 95% of the activity can be recovered by addition of 10 mM dithiothreitol in the reaction mixture; inhibition can not be prevented in the presence of beta-ketoadipate Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O Pseudomonas putida the enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase ?
-
 ?
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O Acinetobacter calcoaceticus the enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
-
-
Pseudomonas putida
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O 3-oxoadipate enol-lactone Pseudomonas putida 3-oxoadipate
-
 ?
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O 3-oxoadipate enol-lactone Acinetobacter calcoaceticus 3-oxoadipate
-
 ?
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O the enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase Pseudomonas putida ?
-
 ?
(5-oxo-4,5-dihydrofuran-2-yl)acetic acid + H2O the enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase Acinetobacter calcoaceticus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
10
-
 3-oxoadipate
-
 Pseudomonas putida
17
-
 3-oxoadipate
-
 Acinetobacter calcoaceticus