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Literature summary for 3.1.1.116 extracted from

  • Okubo, Y.; Kasamatsu, A.; Yamatoji, M.; Fushimi, K.; Ishigami, T.; Shimizu, T.; Kasama, H.; Shiiba, M.; Tanzawa, H.; Uzawa, K.
    Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression (2018), Exp. Cell Res., 367, 112-118 .
    View publication on PubMed
Search for more literature for 3.1.1.116

Application

Application Comment Organism
medicine diacylglycerol lipase alpha (DAGLA) may be a key determinant in tumoral progression and might be a therapeutic target in oral squamous cell carcinomas (OSCCs) Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation and cell-cycle analysis of enzyme deficient siDAGLA cells. Overexpression of DAGLA controls cellular proliferation in OSCC cells and clinical samples through cell-cycle progression. DAGLA-positive OSCC is correlated highly with the primary tumoral size. OSCC cells (KOSC-2 and Ho-1-N-1) are injected subcutaneously into the backs of female nude mice. The tumoral volume of the orlistat-treated group is clearly smaller than that of the control group. DAGLA inhibitor orlistat does not affect the body weight of the mice compared with the control group Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
orlistat
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-acyl-2-arachidonoyl-sn-glycerol + H2O Homo sapiens
-
 2-arachidonoylglycerol + fatty acid
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4D2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
Ca9-22 cell an OSCC cell line Homo sapiens
-
HO-1-N-1 cell an OSCC cell line Homo sapiens
-
Ho-1-u-1 cell an OSCC cell line Homo sapiens
-
HSC-2 cell an OSCC cell line Homo sapiens
-
HSC-3 cell an OSCC cell line Homo sapiens
-
HSC-4 cell an OSCC cell line Homo sapiens
-
KOSC-2 cell an OSCC cell line Homo sapiens
-
additional information real-time quantitative reverse transcription PCR, immunoblotting, and immunohistochemic enzyme analysis, upregulation of DAGLA in OSCC cells Homo sapiens
-
oral squamous cell carcinoma cell primary OSCC cells Homo sapiens
-
Sa-3 cell an OSCC cell line Homo sapiens
-
SAS cell an OSCC cell line Homo sapiens
-
spinal cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acyl-2-arachidonoyl-sn-glycerol + H2O
-
 Homo sapiens 2-arachidonoylglycerol + fatty acid
-
 r

Synonyms

Synonyms Comment Organism
DAGLA
-
 Homo sapiens
diacylglycerol lipase alpha
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown models in OSCC-derived cell lines for DAGLA (siDAGLA) and treatment with a lipase inhibitor (orlistat) show several depressed cellular functions, including cellular proliferation and migratory activities through cell-cycle arrest at G1 phase Homo sapiens
physiological function diacylglycerol lipase alpha (DAGLA), which catalyzes the hydrolysis of diacylglycerol to 2-arachidonoylglycerol and free fatty acid, is required for axonal growth during the brain development and for retrograde synaptic signaling at mature synapses. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. DAGLA-positive oral squamous cell carcinomas (OSCCs) samples are correlated highly with the primary tumoral size. DAGLA may be a key determinant in tumoral progression and might be a therapeutic target for OSCCs Homo sapiens