BRENDA - Enzyme Database
show all sequences of 3.1.1.106

Analysis of O-acetyl-ADP-ribose as a target for nudix ADP-ribose hydrolases

Rafty, L.; Schmidt, M.; Perraud, A.; Scharenberg, A.; Denu, J.; J. Biol. Chem. 277, 47114-47122 (2002)
No PubMed abstract available

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Saccharomyces cerevisiae
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Saccharomyces cerevisiae
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Saccharomyces cerevisiae
-
ADP-D-ribose + acetate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
3T3 cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
751012
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751012
Saccharomyces cerevisiae
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751012
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751012
Saccharomyces cerevisiae
ADP-D-ribose + acetate
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Saccharomyces cerevisiae
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Saccharomyces cerevisiae
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Saccharomyces cerevisiae
-
ADP-D-ribose + acetate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
3T3 cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
751012
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751012
Saccharomyces cerevisiae
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751012
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751012
Saccharomyces cerevisiae
ADP-D-ribose + acetate
-
-
-
?
Other publictions for EC 3.1.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750645
Agnew
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Homo sapiens, Mus musculus
Front. Microbiol.
9
20
2018
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2
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4
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8
2
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2
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4
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5
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8
2
-
-
-
-
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-
-
-
-
-
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-
-
752262
Haikarainen
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Homo sapiens
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23
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2018
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1
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5
-
-
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-
3
-
2
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3
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4
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1
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4
5
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3
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1
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3
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752189
Haikarainen
Proximal ADP-ribose hydrolysi ...
Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Sci. Rep.
6
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2016
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2
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9
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2
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9
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2
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2
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9
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2
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9
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751419
Zhang
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Escherichia coli
J. Struct. Biol.
192
478-486
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1
1
4
-
-
3
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1
-
1
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-
1
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2
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3
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1
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1
4
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3
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1
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1
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2
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3
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3
3
749471
Hirsch
Transition-state analysis of ...
Homo sapiens
ACS Chem. Biol.
9
2255-2262
2014
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-
1
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2
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2
-
2
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2
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2
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1
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2
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2
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2
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2
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2
2
751688
Rosenthal
Macrodomain-containing protei ...
Homo sapiens
Nat. Struct. Mol. Biol.
20
502-507
2013
-
-
1
-
1
-
-
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-
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6
-
5
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1
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-
-
13
-
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-
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3
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-
1
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6
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3
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13
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1
3
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-
751029
Chen
Identification of macrodomain ...
Escherichia coli, Homo sapiens, Staphylococcus aureus
J. Biol. Chem.
286
13261-13271
2011
-
-
1
1
15
-
3
4
-
-
-
8
-
8
-
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1
-
-
1
-
-
12
-
-
-
-
18
-
-
-
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1
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1
-
1
15
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-
4
1
4
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-
8
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-
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1
-
2
-
-
12
-
-
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-
18
-
-
-
-
-
-
-
-
4
4
751030
Kasamatsu
Hydrolysis of O-acetyl-ADP-ri ...
Homo sapiens
J. Biol. Chem.
286
21110-21117
2011
-
-
-
-
-
-
4
1
-
1
-
1
-
1
-
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-
-
-
-
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6
1
-
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-
-
1
-
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3
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3
4
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1
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1
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1
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6
1
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-
-
1
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-
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-
-
-
-
-
-
752026
Ono
The 39-kDa poly(ADP-ribose) g ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
1
-
-
-
3
-
2
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1
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2
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1
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2
1
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1
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1
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3
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2
1
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1
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2
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2
1
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-
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-
-
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-
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-
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-
-
751012
Rafty
-
Analysis of O-acetyl-ADP-ribo ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
47114-47122
2002
-
-
-
-
-
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-
-
2
-
-
4
-
2
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3
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4
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2
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4
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3
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4
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