MacroD1 is a promiscuous ADP-ribosyl hydrolase localized to mitochondria
Agnew, T.; Munnur, D.; Crawford, K.; Palazzo, L.; Mikoc, A.; Ahel, I.; Front. Microbiol. 9, 20 (2018) 
Data extracted from this reference:
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Mus musculus
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Mus musculus
-
ADP-D-ribose + acetate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
Q922B1
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Homo sapiens
-
heart
-
Mus musculus
-
HeLa cell
-
Homo sapiens
-
skeletal muscle
highest expression
Homo sapiens
-
skeletal muscle
highest expression
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
750645
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
750645
Mus musculus
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
750645
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
750645
Mus musculus
ADP-D-ribose + acetate
-
-
-
?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro
750645
Homo sapiens
?
-
-
-
?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro
750645
Mus musculus
?
-
-
-
?
additional information
no activity with ADP-ribosylated thymidine on single stranded DNA
750645
Homo sapiens
?
-
-
-
-
additional information
no activity with ADP-ribosylated thymidine on single stranded DNA
750645
Mus musculus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 28000, SDS-PAGE
Homo sapiens
?
x * 28000, SDS-PAGE
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Mus musculus
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Mus musculus
-
ADP-D-ribose + acetate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Homo sapiens
-
heart
-
Mus musculus
-
HeLa cell
-
Homo sapiens
-
skeletal muscle
highest expression
Homo sapiens
-
skeletal muscle
highest expression
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
750645
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
750645
Mus musculus
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
750645
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
750645
Mus musculus
ADP-D-ribose + acetate
-
-
-
?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro
750645
Homo sapiens
?
-
-
-
?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro
750645
Mus musculus
?
-
-
-
?
additional information
no activity with ADP-ribosylated thymidine on single stranded DNA
750645
Homo sapiens
?
-
-
-
-
additional information
no activity with ADP-ribosylated thymidine on single stranded DNA
750645
Mus musculus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 28000, SDS-PAGE
Homo sapiens
?
x * 28000, SDS-PAGE
Mus musculus
Other publictions for EC 3.1.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750645
Agnew
MacroD1 is a promiscuous ADP- ...
Homo sapiens, Mus musculus
Front. Microbiol.
9
20
2018
-
-
-
-
-
-
-
-
2
-
-
4
-
4
-
-
-
-
-
5
-
-
8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
5
-
-
8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752262
Haikarainen
Development of an inhibitor s ...
Homo sapiens
SLAS Discov.
23
255-263
2018
-
-
1
-
-
-
5
-
-
-
-
3
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
4
5
-
-
-
-
-
3
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752189
Haikarainen
Proximal ADP-ribose hydrolysi ...
Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Sci. Rep.
6
24213
2016
-
-
2
2
-
-
-
-
-
-
-
9
-
8
-
-
2
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
9
-
-
-
2
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751419
Zhang
Structural insights into the ...
Escherichia coli
J. Struct. Biol.
192
478-486
2015
-
-
1
1
4
-
-
3
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
1
4
-
-
-
-
3
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
3
3
749471
Hirsch
Transition-state analysis of ...
Homo sapiens
ACS Chem. Biol.
9
2255-2262
2014
-
-
1
-
-
-
-
2
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
751688
Rosenthal
Macrodomain-containing protei ...
Homo sapiens
Nat. Struct. Mol. Biol.
20
502-507
2013
-
-
1
-
1
-
-
-
-
-
-
6
-
5
-
-
1
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
3
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
751029
Chen
Identification of macrodomain ...
Escherichia coli, Homo sapiens, Staphylococcus aureus
J. Biol. Chem.
286
13261-13271
2011
-
-
1
1
15
-
3
4
-
-
-
8
-
8
-
-
1
-
-
1
-
-
12
-
-
-
-
18
-
-
-
-
1
-
-
-
-
1
-
1
15
-
-
4
1
4
-
-
-
8
-
-
-
1
-
2
-
-
12
-
-
-
-
18
-
-
-
-
-
-
-
-
4
4
751030
Kasamatsu
Hydrolysis of O-acetyl-ADP-ri ...
Homo sapiens
J. Biol. Chem.
286
21110-21117
2011
-
-
-
-
-
-
4
1
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
3
4
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
752026
Ono
The 39-kDa poly(ADP-ribose) g ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
1
-
-
-
3
-
2
-
-
1
-
2
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751012
Rafty
-
Analysis of O-acetyl-ADP-ribo ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
47114-47122
2002
-
-
-
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
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-
-
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-
-
-
-
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-
2
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4
-
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-
3
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4
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-
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-