Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.2.33 extracted from

  • Ohtake, S.; Kondo, S.; Morisaki, T.; Matsumura, K.; Kimata, K.; Habuchi, O.
    Expression of sulfotransferases involved in the biosynthesis of chondroitin sulfate E in the bone marrow derived mast cells (2008), Biochim. Biophys. Acta, 1780, 687-695.
    View publication on PubMed
Search for more literature for 2.8.2.33

Inhibitors

Inhibitors Comment Organism Structure
beta-O-phenyl-GalNAc(4SO4) inhibition of the enzyme in vitro Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin Mus musculus chondroitin sulfate E is synthesized in bone marrow-derived mast cells through the sequential sulfation by chondroitin 4-sulfotransferase (C4ST)-1 and GalNAc4S-6ST, it is a key enzyme for the synthesis of chondroitin sulfate E in bone marrow-derived mast cells adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91XQ5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BMMC cell the expression GalNAc4S-6ST increases during differentiation from bone marrow cells to bone marrow-derived mast cells, the expression in bone marrow-derived mast cells is 3fold higher, than the expression in bone marrow cells Mus musculus
-
bone marrow
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin
-
 Mus musculus adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin chondroitin sulfate E is synthesized in bone marrow-derived mast cells through the sequential sulfation by chondroitin 4-sulfotransferase (C4ST)-1 and GalNAc4S-6ST, it is a key enzyme for the synthesis of chondroitin sulfate E in bone marrow-derived mast cells Mus musculus adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
GalNAc 4-sulfate 6-O-sulfotransferase
-
 Mus musculus
GalNAc4S-6ST
-
 Mus musculus
mGalNAc4S-6ST
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 the optimal pH of sulfation of chondroitin sulfate A is around pH 6.8 Mus musculus