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Literature summary for 2.8.2.33 extracted from

  • ten Dam, G.B.; van de Westerlo, E.M.; Purushothaman, A.; Stan, R.V.; Bulten, J.; Sweep, F.C.; Massuger, L.F.; Sugahara, K.; van Kuppevelt, T.H.
    Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding (2007), Am. J. Pathol., 171, 1324-1333.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.33

Application

Application Comment Organism
medicine tumor-specific chondroitin sulfate modifications might be potential targets to influence tumor development Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cell matrix, SKOV-3 cell Homo sapiens 5737
-
membrane OVCAR-3 cell Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin Homo sapiens involved in biosynthesis of chondroitin sulfate E, is one of the final steps in the chondroitin sulfate pathway creating disulfated GalNAc residues adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7LFX5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
OVCAR-3 cell
-
 Homo sapiens
-
OVCAR-4 cell low level of expression Homo sapiens
-
SKOV-3 cell highest expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin
-
 Homo sapiens adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin involved in biosynthesis of chondroitin sulfate E, is one of the final steps in the chondroitin sulfate pathway creating disulfated GalNAc residues Homo sapiens adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
GalNAc4S 6-O-sulfotransferase
-
 Homo sapiens
GalNAc4S-6ST
-
 Homo sapiens