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Literature summary for 2.8.2.2 extracted from

  • Bi, Y.; Shi, X.; Zhu, J.; Guan, X.; Garbacz, W.G.; Huang, Y.; Gao, L.; Yan, J.; Xu, M.; Ren, S.; Ren, S.; Liu, Y.; Ma, X.; Li, S.; Xie, W.
    Regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis (2018), Mol. Cell. Biol., 38, e00654-17 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.2

Application

Application Comment Organism
medicine the HNF4alpha-SULT2B1b-CS axis represents a key endogenous mechanism to prevent uncontrolled gluconeogenesis. Thiocholesterol may be used as a therapeutic agent to manage hyperglycemia Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + cholesterol Homo sapiens
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + cholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00204
-
-
Mus musculus O35400
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
hepatocyte
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Mus musculus
-
primary cell
-
 Homo sapiens
-
primary cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + cholesterol
-
 Homo sapiens adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + cholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol sulfotransferase
-
 Homo sapiens
cholesterol sulfotransferase
-
 Mus musculus
SULT2B1b
-
 Homo sapiens
SULT2B1b
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens the basal expression levels of SULT2B1b and G6Pase ae decreased in human primary epatocytes treated with the HNF4alpha inhibitor BIM5078 down
Homo sapiens HNF4alpha induces the expression of SULT2B1b in human liver cells. In the human hepatoma HepG2 cells, transfection with the HNF4alpha expression vector increases the expression of SULT2B1b. In human primary hepatocytes (HPH), treatment of cells with the HNF4alpha activator linoleic acid induces the expression of both SULT2B1b up
Mus musculus HNF4alpha positively regulates the expression of Sult2B1b in mouse primary hepatocytes and in mouse liver, expression of Sult2B1b is induced by HNF4alpha upon fasting up

General Information

General Information Comment Organism
malfunction downregulation or ablation of Sult2B1b enhances the gluconeogenic activity of HNF4alpha, which may cause increased acetylation of HNF4alpha as a result of decreased expression of the HNF4alpha deacetylase sirtuin 1 (Sirt1). Sult2B1b-/- mice exhibit elevated fasting blood glucose levels. Thiocholesterol is a hydrolysis-resistant derivative of cholesterol, which shows superior activity to that of the native cholesterol in inhibiting gluconeogenesis and improving insulin sensitivity in high-fat-diet-induced diabetic mice Mus musculus
metabolism regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis. The SULT2B1b gene is a transcriptional target of HNF4alpha Homo sapiens
metabolism regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis. The SULT2B1b gene is a transcriptional target of HNF4alpha. Recruitment of HNF4alpha to the mouse Sult2B1b gene promoter is confirmed by chromatin immunoprecipitation assay on mouse primary hepatocytes Mus musculus
physiological function sulfotransferases (SULTs) catalyze the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor molecule. Sulfation plays an essential role in regulating the chemical and functional homeostasis of endogenous and exogenous molecules. The cholesterol sulfotransferase SULT2B1b preferentially catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate. SULT2B1b inhibits hepatic gluconeogenesis by antagonizing the gluconeogenic activity of hepatocyte nuclear factor 4alpha (HNF4alpha). Regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis. SULT2B1b also plays a restrictive role in HNF4alpha-mediated fasting-responsive gluconeogenesis Homo sapiens
physiological function sulfotransferases (SULTs) catalyze the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor molecule. Sulfation plays an essential role in regulating the chemical and functional homeostasis of endogenous and exogenous molecules. The cholesterol sulfotransferase SULT2B1b preferentially catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate. SULT2B1b inhibits hepatic gluconeogenesis by antagonizing the gluconeogenic activity of hepatocyte nuclear factor 4alpha (HNF4alpha). Regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis. SULT2B1b also plays a restrictive role in HNF4alpha-mediated fasting-responsive gluconeogenesis Mus musculus