BRENDA - Enzyme Database
show all sequences of 2.8.2.2

Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury

Wang, Z.; Yang, X.; Chen, L.; Zhi, X.; Lu, H.; Ning, Y.; Yeong, J.; Chen, S.; Yin, L.; Wang, X.; Li, X.; Arch. Toxicol. 91, 271-287 (2016)

Data extracted from this reference:

Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
O35400
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
hepatic oval cell
-
Mus musculus
-
WB-F344 cell
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3'-phosphoadenylylsulfate + 22-hydroxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 22-hydroxycholesterol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 24,25-epoxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 24,25-epoxycholesterol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 25-hydroxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 25-hydroxycholesterol sulfate
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
hydroxysteroid sulfotransferase 2B1b
-
Mus musculus
SULT2B1b
-
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
hepatic oval cell
-
Mus musculus
-
WB-F344 cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3'-phosphoadenylylsulfate + 22-hydroxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 22-hydroxycholesterol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 24,25-epoxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 24,25-epoxycholesterol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 25-hydroxycholesterol
-
737574
Mus musculus
adenosine 3',5'-bisphosphate + 25-hydroxycholesterol sulfate
-
-
-
?
Expression
Organism
Commentary
Expression
Mus musculus
the expression of SULT2B1b is increased dramatically in a chemical-induced liver injury model, mainly in hepatic oval cells
up
General Information
General Information
Commentary
Organism
physiological function
upregulation of SULT2B1b promotes hepatic oval cell proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
upregulation of SULT2B1b promotes hepatic oval cell proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
the expression of SULT2B1b is increased dramatically in a chemical-induced liver injury model, mainly in hepatic oval cells
up
Other publictions for EC 2.8.2.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737574
Wang
Upregulation of hydroxysteroid ...
Mus musculus
Arch. Toxicol.
91
271-287
2016
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1
1
1
1
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738123
Ekuase
Mechanistic insights into the ...
Homo sapiens
Environ. Sci. Pollut. Res. Int.
23
2119-2127
2016
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1
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5
5
1
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5
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5
5
738296
Rizner
The important roles of steroid ...
Homo sapiens
Front. Pharmacol.
7
30
2016
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3
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3
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9
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3
1
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2
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2
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738482
Zhang
Sulfation of benzyl alcohol by ...
Homo sapiens
J. Appl. Toxicol.
36
1090-1094
2016
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1
1
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3
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3
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6
3
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3
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2
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1
1
738909
Bansal
Human liver cytosolic sulfotra ...
Homo sapiens
J. Pharm. Biomed. Anal.
120
261-269
2016
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1
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1
1
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737572
Maiti
Ethanol up-regulates phenol su ...
Rattus norvegicus
Arch. Physiol. Biochem.
121
68-74
2015
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1
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1
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1
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738101
Shao
Exogenous dopamine induces deh ...
Rattus norvegicus
Drug Metab. Pharmacokinet.
30
97-104
2015
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1
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1
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1
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739274
Chen
Detoxification function of the ...
Arabidopsis thaliana
Plant Cell Environ.
38
1673-1682
2015
-
-
1
-
-
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-
10
1
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6
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3
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27
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1
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9
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1
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10
1
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3
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27
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9
-
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1
1
-
9
9
738032
Ekuase
Binding interactions of hydrox ...
Homo sapiens
Chem. Biol. Interact.
212
56-64
2014
-
-
1
-
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-
15
-
-
-
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-
1
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1
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1
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2
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15
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1
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15
15
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1
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1
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739057
Shi
Cholesterol sulfate and choles ...
Mus musculus
Mol. Cell. Biol.
34
485-497
2014
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1
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1
1
1
1
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726332
Yang
Hydroxysteroid sulfotransferas ...
Homo sapiens
PLoS ONE
8
e60853
2013
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1
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1
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3
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1
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2
2
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703834
Rahman
Characterization of iodothyron ...
Lithobates catesbeianus
Gen. Comp. Endocrinol.
166
396-403
2010
-
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12
3
2
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6
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3
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2
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6
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3
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10
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12
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3
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6
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2
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6
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1
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1
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690709
Liu
Immunohistochemical analysis o ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
367
14-20
2008
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1
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2
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1
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4
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1
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690852
Kocarek
Age- and sex-dependent express ...
Mus musculus
Biochem. Pharmacol.
76
1036-1046
2008
-
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1
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2
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1
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1
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1
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691779
Gulcan
Pentachlorophenol and other ch ...
Homo sapiens
Chem. Res. Toxicol.
21
1503-1508
2008
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1
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692086
Khor
Gender-specific expression and ...
Mus musculus
Endocrinology
149
5440-5448
2008
1
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1
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1
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694259
Lu
Identification and characteriz ...
Homo sapiens
Mol. Pharmacol.
73
660-668
2008
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1
12
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3
17
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2
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1
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2
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2
1
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1
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16
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1
12
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3
16
17
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2
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2
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1
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1
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675275
Fuda
Oxysterols are substrates for ...
Homo sapiens
J. Lipid Res.
48
1343-1352
2007
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1
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1
1
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3
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2
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1
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3
5
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14
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9
1
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1
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2
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1
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5
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14
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1
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1
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675604
Ji
Human hydroxysteroid sulfotran ...
Homo sapiens
J. Pharmacol. Exp. Ther.
322
529-540
2007
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1
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5
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2
1
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2
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1
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7
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1
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7
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676745
Allali-Hassani
-
Structural and chemical profil ...
Homo sapiens
PLoS Biol.
5
1063-1078
2007
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1
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5
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1
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1
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1
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1
3
1
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3
1
1
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1
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677218
Chen
Human constitutive androstane ...
Homo sapiens
Toxicology
231
224-233
2007
1
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1
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1
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1
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692098
Harris
Effects of endocrine disruptor ...
Homo sapiens
Environ. Health Perspect.
115 Suppl 1
51-54
2007
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1
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5
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1
1
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1
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3
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4
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2
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2
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1
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1
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5
1
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1
1
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1
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4
-
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2
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1
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693816
Fang
Positive and negative regulati ...
Homo sapiens
J. Pharmacol. Exp. Ther.
323
586-598
2007
1
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1
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1
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694547
Reich
Estrogen sulfotransferase expr ...
Homo sapiens
Pathol. Res. Pract.
203
85-87
2007
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1
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1
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2
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5
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1
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1
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1
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1
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2
1
3
1
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2
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1
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1
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-
1
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3
3
1
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1
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1
1
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2
1
1
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2
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1
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2
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3
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2
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1
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1
1
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1
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Enantioselectivity of human hy ...
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Human type 1 estrogen sulfotra ...
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Sulfation of budesonide by hum ...
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17Beta-hydroxysteroid dehydrog ...
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645783
Falany
Human dehydroepiandrosterone s ...
Homo sapiens
Ann. N. Y. Acad. Sci.
774
59-72
1995
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7
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7
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18
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645782
Barker
Dehydroepiandrosterone sulfotr ...
Homo sapiens
Endocrinology
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1994
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645780
Comer
-
Cloning and expression of huma ...
Homo sapiens
Biochem. J.
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1993
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645781
Driscoll
Isolation of two distinct 3-hy ...
Cavia porcellus
J. Biol. Chem.
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23496-23503
1993
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9
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645778
Hernandez
Sulfation of estrone and 17bet ...
Homo sapiens
Drug Metab. Dispos.
20
413-422
1992
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645779
Kong
Molecular cloning of the alcoh ...
Homo sapiens
Biochem. Biophys. Res. Commun.
187
448-454
1992
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645777
Bouthillier
The purification of 3beta-hydr ...
Mesocricetus auratus
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1985
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645775
Bouthillier
Steroid sulfotransferase in ha ...
Mesocricetus auratus
Steroids
38
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1981
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645776
Lyon
Hydroxysteroid sulfotransferas ...
Rattus norvegicus
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77
206-213
1981
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9
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645774
Lyon
The identity of alcohol sulfot ...
Rattus norvegicus
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202
474-481
1980
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645773
Ryan
Studies on a 3beta-hydroxyster ...
Rattus norvegicus
Biochim. Biophys. Acta
429
391-401
1976
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2
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