Literature summary for 2.8.2.2 extracted from

Fang, H.L.; Strom, S.C.; Ellis, E.; Duanmu, Z.; Fu, J.; Duniec-Dmuchowski, Z.; Falany, C.N.; Falany, J.L.; Kocarek, T.A.; Runge-Morris, M.
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor (2007), J. Pharmacol. Exp. Ther., 323, 586-598.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	rifampicin induces SULT2A1 expression about 12fold in a manner dependent on 5'-flanking regions containing rifampicin-responsive information as a hepatocyte nuclear factor 4, HNF4, binding site. Upregulation of SULT2A1 does not occur in cells, that do not contain the binding site. Binding of HNF4 to the HNF4-54 region of the endogenous SULT2A1 gene leads to increased SULT2A1 mRNA production and enzyme activity, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
transient expression of SULT2A1 in Hep-G2 cells, expression analysis in presence or absence of rifampicin and/or PXR, regulation, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	rifampicin-liganded PXR suppresses SULT2A1 expression by interfering with HNF4alpha activity, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary culture	Homo sapiens	-
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
hydroxysteroid sulfotransferase	-	Homo sapiens
SULT2A1	-	Homo sapiens

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Release 2023.1 (January 2023)