Literature summary for 2.8.2.1 extracted from

Luo, L.; Zhou, C.; Hui, Y.; Kurogi, K.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin (2016), Drug Metab. Pharmacokinet., 31, 163-166 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75897	isoform SULT1C4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00185	-	substrate doxorubicin, pH 7.0, 37°C	Homo sapiens
0.00504	-	substrate epirubicin, pH 7.0, 37°C	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + doxorubicin	-	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	?
3'-phosphoadenylyl sulfate + epirubicin	-	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	?

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Release 2023.1 (January 2023)