Literature summary for 2.7.8.B10 extracted from

Jeucken, A.; Helms, J.; Brouwers, J.
Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids (2018), Biochim. Biophys. Acta, 1863, 1345-1353 .

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A6H8	isoform ClsA	-
Escherichia coli	P0AA84	isoform ClsB	-

Synonyms

Synonyms	Comment	Organism
clsA	-	Escherichia coli
clsB	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	a minor decrease of cardiolipin content is observed in the ClsA overexpression strain. Phosphatidylethanolamine and phosphatidylglycerol levels remain unaltered upon overexpression of ClsA. ClsA deletion leads to abolishment of phosphytidylcholine-dependent phosphatidylalcohol formation	Escherichia coli
physiological function	a modest increase of cardiolipin content is observed in the ClsB overexpression strain. Overexpression of ClsB also leads to an increase of phosphatidylethanolamine from 67% to 79% and a decrease of phosphatidylglycerol content from 31% to 14% of phospholipids. Overexpression of ClsB leads to formation of phosphatidylalcohols whereas levels of phosphatidylalcohols are unaltered in the clsB knockout mutant	Escherichia coli

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Release 2023.1 (January 2023)